Hi, If your computer is not affected with any malware, then i say that all in one tool in safe mode could fix all permission issues to default. Instead of clicking all the repair, you could choose safe mode and permission to run. It will fix all permission issues. It is my experience whenever access problem occurs.
If it fails, then run malwarebytes and see the result to confirm that it is a malware infection that deletes the general permission. Hope that this helps